TARDBP and amyotrophic lateral sclerosis: Of note, human homologues SERF1 and SERF2 share low-level homology with the RNA-binding domain of Matrin3 (Scharf et al., 1998) a protein that colocalises with small nuclear ribonucleoproteins (snRNPs), interacts with TDP-43, and has been recently identified as a novel disease marker for some rare forms of ALS (Johnson et al., 2014).