VCP and amyotrophic lateral sclerosis: For instance, expression of mutant valosin-containing protein (VCP, a member of the type II AAA+ ATPase family with a number of cellular functions including mitochondrial quality control, autophagy, vesicle transport and fusion, 26 S proteasome function, and assembly of peroxisomes) found in ALS patients makes human neuroblastoma SH-SY5Y cells susceptible to OS induced by treatment with L-buthionine sulfoximine, an inhibitor of the synthesis of glutathione (GSH; Hirano et al., 2014).