SOD1 and amyotrophic lateral sclerosis: Disturbance of mitochondrial Ca2+ transport in ALS have been widely described in SOD1 models in vitro and in vivo by the group of B. Keller (Jaiswal and Keller, 2009; Jaiswal et al., 2009) and by others; this aspect has been recently reviewed in detail (Barrett et al., 2014; Tadic et al., 2014) and thus we will not discuss it in this paper.