MYLK and brain edema: Another study has revealed that the inhibition of a kinase involved in the development of brain edema, myosin light-chain kinase, by the administration of an inhibitor, ML-7, to P24 mice starting 4 h after TBI and every 24 h until sacrifice, significantly reduces BBB breakdown and the development of cerebral edema, and preserves neurological function (Rossi et al., 2013).