GPT and infection: In univariate analysis, apart from rs12979860, significant fibrosis was associated with the previously reported risk factors of older age, male sex, higher body mass index (BMI), higher alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase, γ-glutamyl transpeptidase (GGT), bilirubin and lower platelet counts, infection with HCV genotype 3 and with moderate–severe hepatic inflammation.