In the OM + HA + US group, the mean Zp4 expression level was estimated as 373.212 ± 341.75 number of copies, whereas in the HA + US group, it was 852.0 ± 742.0, in the OM + US group, it was 636.7 ± 516.51 and in the OM + HA group, it was 124.1 ± 137.8. This evidence concerns the gene ZP4 and ocular melanoma.