Results indicated that the mRNA level of STC1 was significantly up-regulated in ccRCC tissues (both in localized, P < 0.01, and metastatic tissues, P < 0.01; Figure 1A) compared with adjacent normal renal tissues, with the greatest expression observed in metastatic tissues (P < 0.01, Figure 1A). Here, STC1 is linked to nonpapillary renal cell carcinoma.