To evaluate STC1 expression in ccRCC cell in vitro, metastatic RCC cell lines (Caki-1, SN12-PM6), non-metastatic cell lines (A498, Caki-2) and human renal proximal tubular epithelial cell line HKC were analyzed by RT-PCR and western blotting. Here, STC1 is linked to nonpapillary renal cell carcinoma.