TARDBP and amyotrophic lateral sclerosis: Treatment of the zebrafish containing TDP-43 mutant mRNA Tg (olig2:dsred2) with TS at 9 hours postfertilization (hpf), before the onset of axonal outgrowth, significantly prevented defects in axons and NMJ degeneration in the zebrafish model of ALS in a dose-dependent manner (p = 2.4 × e−13; Fig. 4A, B).