AURKB and leukemia: This is an important consideration since medulloblastoma is often treated with multiple chemotherapeutic drugs, including inhibitors of DNA synthesis such as methotrexate and topoisomerase inhibitors.[41] A synergistic effect on blocking cell proliferation has been shown by Aurora B inhibition and concurrent inhibition of DNA synthesis with Topoisomerase II inhibitor daunorubicin in human leukemia.[42]