Downregulation of the serine/threonine kinase Ark5/Nuak1 has been shown to promote cell death in MYC expressing cells.[33] Furthermore, LATS1 levels are regulated by Ark5/Nuak1 phosphorylation and LATS1 is needed for activation of Aurora B.[34, 35] In order to confirm the specificity of AZD1152-HQPA action on Aurora B independent of Ark5/Nuak1, we probed for changes in LATS1 levels upon continuous medulloblastoma cell exposure to AZD1152-HQPA for up to 96 hours. The gene discussed is MARK2; the disease is medulloblastoma.