AURKB and colon carcinoma: Prior reports of Aurora B inhibition in colon carcinoma cells with ZM447439 in which post-mitotic G1 arrest was initiated by forced expression of p21 or p27, showed that endoreplication was required for apoptosis in these cells.[37] We did not observe apoptosis in UW426 and UW228 cells despite the induction of endoreplication in these cells.