MYC and neoplasm: The D425 cell line was derived from primary tumor tissue,[21] whereas the D458 line was derived from cerebrospinal fluid within the same patient after failure of radiotherapy and chemotherapy with cyclophosphamide, cisplatin, and vincristine.[22, 24] As such, our results suggest that the concordance between Aurora B and MYC expression is maintained in the setting of recurrent G3MB.