Restoration of miR-377 inhibits TIAM1-mediated HCC cell proliferation and invasion Western blot of TIAM1 in the HepG2 cells transfected with the pcDNA-TIAM1 or vector control showed that pcDNA-TIAM1 could enhance the TIAM1 protein expression (Fig. 5A). The gene discussed is TIAM1; the disease is hepatocellular carcinoma.