FOXO1 is an important transcription factor downstream of the PI3K-Akt signaling pathway and has been implicated as a tumor suppressor in several cancers, including mesothelioma [26], Ewing’s sarcoma [27], gastric cancer [28], oral cancer [29], prostate cancer [30] and breast cancer [31]. This evidence concerns the gene AKT1 and Ewing sarcoma.