WNK2 and prion disease: Moreover, there were nine significantly related KEGG pathways in the kidney of l-NAME-treated offspring, including circadian rhythm, mitogen-activated protein kinases (MAPK) signaling pathway, colorectal cancer, chemokine signaling pathway, pathways in cancer, Wnt signaling pathway, NOD-like receptor signaling pathway, renal cell carcinoma, and prion diseases.