APLN and hypertensive disorder: In addition to sEH (encoded by Ephx2), several DEGs identified in the present study are related to regulation of BP (GO: 0008217) including Aqp2, Ptgs1, Hba-a2, Apln, Guca2b, Hmox1, and Npy. Aqp2 gene encodes for aquaporin-2; and renal aquaporin-2 is associated with hypertension due to its ability to maintain water balance [24].