In multivariate Cox analysis, LVEF, E/E’, LAVI, E/E’>15, and LAVI>32 mL/m2 were shown to be significant independent predictors of CV events even after adjusting for age, sex, dialysis modality, smoking, history of DM, CAD, CVD and arrhythmia, hemoglobin and serum albumin concentrations, and 24-hour urine volume. The gene discussed is ALB; the disease is cardiac arrhythmia.