In addition, biochemical analyses revealed that mSAA3 is an endogenous ligand for the toll like receptor 4 (TLR4)/MD-2 complex, the epicenter for the innate immune system [11], and also that the S100A8-SAA3-TLR4 cascade is responsible for myeloid-derived cell recruitment in the lungs and attracts circulating tumor cells to the lungs. This evidence concerns the gene TLR4 and neoplasm.