TNF-α is mostly known for its pro-inflammatory properties, however, as anti-TNF treatment leads to exacerbation in MS and TNF-α also has immune-regulatory immune-effects the role of increased TNF in IFN-β treated MS may be complex [50]; 3) The transcription factors TBX21 and HLX1 are primarily associated withTH1 cells, however TBX21 also appears to have a role in TH17 differentiation [51,52]. This evidence concerns the gene IFNB1 and myeloid sarcoma.