CTNNB1 and hepatocellular carcinoma: However, there is a high degree of cell-context dependency in the transcriptional targets of β-catenin activation [25] and as would be expected, CTNNB1-mutant HCC showed a strong tendency to overexpress the five genes previously found to be selectively overexpressed in CTNNB1-mutant HCC (Fig. 4) [26–28].