In addition, recurrent alterations affecting the tumor suppressor genes TP53 and DLC1 have been shown to promote HCC progression [6,7], and more recently, recurrent mutations affecting antioxidant response genes NFE2L2 and KEAP1 and histone methyltransferases genes of the MLL family have been found in multiple cohorts of hepatocellular carcinoma [8–10]. This evidence concerns the gene PRDM9 and hepatocellular carcinoma.