PTEN and pancreatic ductal adenocarcinoma: For example, miR-486 represses the development of pancreatic ductal adenocarcinomas by inhibiting the expression the gene CD40 [11], inhibits SIRT1 deacetylase activity in human adipose tissue-derived mesenchymal stem cells [12], stimulates muscle myoblast differentiation by downregulating Pax7 [13], and downregulating PTEN (phosphatase and tensin homolog) and Foxo1a in muscle cells [14].