In addition, a large part of the interneurons in the spinal cord gray matter consists of glycinergic neurons that are especially responsible for the glycinergic inhibitory neurotransmission (with α3β glycine receptors) in the dorsal horn of the spinal cord.45 The subacute combined neurodegeneration in the posterolateral spinal cord of adult patients with Cbl deficiency indicates that the glycinergic neurons that we believe glycine causes hypotonia through (stimulating glycineA receptors) and the neurons where subacute combined neurodegeneration are observed could be similar neurons. The gene discussed is CBL; the disease is hyperinsulinemic hypoglycemia, familial, 4.