NOTCH3 and central nervous system cancer: NOTCH signaling activation has been demonstrated to be involved in carcinogenesis.6–8 A recent study showed that NOTCH3 activation promotes invasive glioma formation in gliomas in a tissue site-specific manner.9 NOTCH3 is not expressed in normal brain tissues, but is highly expressed in astrocytomas.10 NOTCH3 is a prognostic factor that promotes glioma cell proliferation, migration and invasion.11