However, recent studies reveal that the seemingly non-functional polymorphisms, like 684 G>A, could affect transcription, splicing, mRNA transport or translation, any of which could influence the resultant phenotype.21 In line with this finding, we found in our study that the 684G>A polymorphism can affect the NOTCH3 expression level in tumor tissues from glioma patients. The gene discussed is NOTCH3; the disease is central nervous system cancer.