The G684A alleles were observed to be significantly associated with migraine, while the 381C>T does not affect the migraine risk.21 A recent study reported the interaction between one of the known NOTCH3 gene polymorphism (381C>T) with 2 other genes (MTHFR C677T and ALOX5AP T2354A) to be a significant contributor to thrombotic stroke.22 This evidence concerns the gene MTHFR and migraine disorder.