A recent study indicates that the introduction of activated NOTCH3 into developing ocular tissues induced a number of aggressive neoplasms, including invasive gliomas arising from the optic nerve and retina, while NOTCH1 and NOTCH2 activation does not efficiently generate ocular tumors.9 That was the reason we selected NOTCH3 gene polymorphism in this study. Here, NOTCH2 is linked to central nervous system cancer.