An additional E2F1 target regulated by miR-10b, EZH2, is the catalytic subunit of Polycomb Repressor complex 2, overexpressed in various malignancies, including GBM, that inhibits differentiation, activates cell cycle, increases cell motility, and enhances self-renewal and tumor initiating capacity [46–49]. The gene discussed is E2F1; the disease is glioblastoma.