CDKN1A/p21, the key tumor suppressor that restricts proliferation and induces apoptosis of transformed cells has been identified as a direct target of miR-10b in GBM, along with others that include CDKN2A/p16, BIM, TFAP2C, and TP53 [2, 5]. This evidence concerns the gene CDKN1A and glioblastoma.