We first found that this agent suppressed the phosphorylation of p38, ERK, CREB, Chk-2, STAT5, and RSK in human CML KBM-5 cells, also p53 protein became phosphorylated at Ser392 and Ser46, but not Ser15 in response to ART treatment. This evidence concerns the gene CREB1 and chronic myelogenous leukemia, BCR-ABL1 positive.