These results, suggest that S100A4 is a mediator of C/EBPβ effects specifically on cell migration and invasion capacity of glioblastoma cells and are in accordance with previous reports showing a direct relationship between S100A4 expression and cell migration in astrocytic tumor cells, such as C6 [35], neuroblastoma cells [45] and medulloblastoma cells [46]. This evidence concerns the gene S100A4 and medulloblastoma.