DSG2 and neoplasm: Gene expression analysis of REMBRANDT tissue transcriptomic compendium also indicated higher expression of DSG2 and CD46 receptors relative to non-tumor regions of the brain (Figure 1B).We observed significant differences in expression of DSG2 (p < 0.015) and CD46 (p < 0.0049) in grade III relative to grade IV GBM specimens (Table 1).