ASPG and leukemia: Although primarily used as a chemotherapeutic agent against ALL [11, 12], asparaginase is also used in other types of leukemia such as non-Hodgkin's lymphoma [13], subtypes of myelocytic leukemia [14] and chronic lymphocytic leukemia, sarcomas such as lymphosarcoma, reticulosarcoma and melanosarcoma [15], ovarian cancer [16] and brain cancer [6] with a potential role for its glutaminase activity [10].