ACTA1 and Hepatic fibrosis: The present study investigated the expression of CD147 in the liver of rat models of hepatic fibrosis, induced by CCl4, to determine whether activated HSCs secreted CD147 Following treatment with CCl4 for 4 or 8 weeks, the model rats were sacrificed and the liver tissues were used to detect the expression levels of α-SMA and CD147 by immunohistochemistry and western blotting.