To discriminate patients with early HCC (BCLC 0/A) from those with liver cirrhosis, the sensitivity of MDK at cutoff value 0.387 ng/mL was found to be much significantly higher when compared to that of AFP at cutoff values 20, 88.5, and 200 ng/mL (90% versus 40%, 20%, and 0%, resp., P < 0.001) (Figure 2). Here, AFP is linked to cirrhosis of liver.