In terms of in vivo research, one animal study demonstrated that the median survival time of tumor-bearing mice treated with three different dosages of SHK (2.5, 5.0, or 10.0 mg/kg/day) for 10 days would be prolonged at least for 7 days compared with the sham-treated negative control groups and exhibit hair with a healthier appearance and be more active compared with the 5FU-treated positive control groups [21]. Here, SHPK is linked to neoplasm.