Immunohistochemical evaluation has revealed that most of these lesions are of gonadotroph differentiation, as they usually immunostain for the beta subunit of LH and/or FSH, as well as for the common alpha subunit of these glycoproteic hormones; a small proportion of these patients have tumors that immunostain for ACTH, GH, and TSH, the so-called “silent corticotroph, somatotroph, and thyrotroph adenomas,” respectively [5, 6]. The gene discussed is PLOD1; the disease is adenoma.