As TRAF1, 4-1BB, and Bcl-xL are correlated positively, TRAF1 may trigger 4-1BB–mediated Bcl-xL activity. TRAF1–4-1BB–Bcl-xL signaling pathway upregulation may play a critical role in the development gastritis into gastric cancer. The gene discussed is TNFRSF9; the disease is gastric cancer.