TRAF1 expression in human gastric mucosa is related to the H. pylori virulence genotype cagA+/vacAs1+/vacAm1+ [9], whereas the correlation of 4-1BB and Bcl-xL gene expression with cagA, vacAs1, and vacAm1 toxicity at different stages of gastric disease have not been studied. This evidence concerns the gene BCL2L1 and stomach disorder.