Taken together, our data confirm earlier studies supporting the existence of a profound alteration of some components of the ghrelin system in the most predominant pituitary adenoma subtypes13, 21, 22, and extend previous data by demonstrating the expression of In1-ghrelin and MBOAT4 in pituitary adenomas, which further supports the notion that an autocrine/paracrine functional loop involving the ghrelin system can be in place in the pituitary, and may contribute to the (patho)physiological control of the gland. The gene discussed is MBOAT4; the disease is pituitary gland adenoma.