GHRL and pituitary gland adenoma: In this work, we hypothesized that the ghrelin system could play a role in the regulation of pituitary adenomas, based on previous reports indicating that this system exerts relevant actions in the control of pituitary secretions1, 16, 17, and that some components of this family are altered in certain pituitary adenomas subtypes1, 13, 21, 22, 23.