Obviously, future studies, using larger number of human culture samples and additional, different types of assays are warranted to unequivocally establish if the overexpresion of In1-ghrelin variant observed in all the human pituitary adenomas analyzed herein is directly associated with an increase in proliferation and a decrease in apoptotic rate observed in these human pituitary pathologies. This evidence concerns the gene GHRL and pituitary gland adenoma.