MAPT and Dravet syndrome: In our model, we also detected that the level of Tau protein was dramatically upregulated in the medium of DS neurons (179.36 ± 26.73 pg/mL) compared to that from control TW1 hESC-derived neurons (93.23 ± 9.55 pg/mL), undifferentiated DS iPSCs (56.86 ± 21.49 pg/mL) and TW1 hESCs (24.82 ± 11.62 pg/mL) (Fig. 3c).