JARID1B upregulates AR but acts as a histone demethylase of histone 3 lysine 4 tri(di)methylation (H3K4me3/2) in PCa [51], implicating a connection between SKP2 E3 Ub ligase-mediated ubiquitination and histone modifications. The gene discussed is KDM5B; the disease is posterior cortical atrophy.