Furthermore, the levels of SENP1 protein are higher in LNCaP, DU145, and PC3 PCa cells as compared to that in non-tumorigenic RWPE-1 cells, and SENP1 protein levels are correlated with malignant severities (Gleason scores and pathological stages) in human PCa specimens [98]. Here, SENP1 is linked to posterior cortical atrophy.