TAC1 and neoplasm: We evaluated MI using promoter methylation of SST, SSTR1, TAC1, TACR1, Galanin, GALR1, and GALR2. Hypermethylation of MI was significantly associated with tumor size (P = 0.022), lymph-node status (P = 0.019), stage (P = 0.004), and recurrence events (P = 0.036).