SSTR1 methylation was significantly correlated with tumor size (P = 0.037), stage (P = 0.037), galanin (P = 0.030), GALR2 methylation (P = 0.014), TAC1 methylation (P = 0.023), TAC1R methylation (P = 0.003), H-cadherin methylation (P = 0.007), MGMT methylation (P = 0.001), DAPK methylation (P = 0.001) and DCC methylation (P = 0.045) (Table 1and S1 Table). The gene discussed is TAC1; the disease is neoplasm.