MDM2 and neoplasm: The Cox proportional hazards model was applied to multifactor analysis using the following variables: age (<60 or ≥60 years), gender, smoking history, body mass index (BMI, <20 or ≥20), TNM staging, TP53 codon 72 genotype (Pro/Pro or not), MDM2 SNP 309 genotype (G/G or not), IHC of TP53 and MDM2, and the existence of tumor-node-metastases.