In order to find out whether the degree of hypoxia has correlation with the expression of individual or collective Notch genes, we arranged the tumors in decreasing order of HIF-1α expression and grouped them by tertiles as: high (≥ 3.6-fold; 12 tumors); intermediate (3.5 to 0.8-fold; 11 tumors) and low (≤ 0.8-fold; 12 tumors) HIF-1α GBM tertiles. This evidence concerns the gene HIF1A and glioblastoma.