However, their expression in these cells was not able to completely inhibit the phosphorylation of eIF2α during infection with VACVΔE3LΔK3L (Fig. 3A; lane 7 vs. lane 8), which may explain the slight reduction in replication observed for this virus in the RK13+E3L+K3L cells compared to the wild-type. Here, EIF2A is linked to infection.