Our data demonstrated that while LY294002 or AKT I inhibited the induced migration of the wild-type (WT) and the non-targeting lentivirus infected (NC) breast cancer cells at day 7 post-IR, neither LY294002 nor AKT I affected the migration of Bmi-1 knockdown (shBmi-1) breast cancer cells (Fig. 4, shBmi-1 vs. NC or WT). The gene discussed is BMI1; the disease is breast cancer.