DUSP6 and mood disorder: The downregulation of DUSP6 has also been reported in the PFC of individuals with bipolar disorder.43 Furthermore, genetic variation within and proximal to DUSP6 has been associated with bipolar disorder and lithium-induced ERK activation,44 a mechanism related to neuroplasticity and neurogenesis,45 suggesting a role for DUSP6 in the regulation of mood disorders, neuroplasticity and neurogenesis.