Consequently, as indicated by t-test (p < 0.01), the pre-incubation of CLL cells with U73122 prior to PKHB1 treatment significantly decreased PCD (a mean of ~50% Annexin-V/PI co-positivity was measured in U73122-untreated cells and a mean of ~18% in B lymphocytes pre-incubated with U73122) (Fig. 6D). Here, ANXA5 is linked to B-cell chronic lymphocytic leukemia.