First, it is a translational study with three parts: (i) generation of PKHB1 (a serum-stable CD47 peptide agonist), (ii) analysis of the biological activity of PKHB1 in vitro on a panel of primary B lymphocytes that reproduced the diversity of CLL patients and incorporated the cytogenetic abnormalities that are associated with CLL refractoriness, and (iii) an in vivo approach to assess the effect of PKHB1 on a CLL mouse model, which revealed that this peptide reduces tumor burden without apparent side effects. Here, CD47 is linked to B-cell chronic lymphocytic leukemia.