In order to better characterize the effect of the CD47 agonist peptide PKHB1 in high-risk CLL patients, we compared the response of cells with functional and dysfunctional TP53 (characterized in S4 Fig and Table 3) to PKHB1 and the P53-dependent PCD inducer etoposide. Here, CD47 is linked to B-cell chronic lymphocytic leukemia.