Thus, future work should analyze whether PLCγ1 over-expression plays a role in CLL survival; whether ZAP70 or other SRC, SYK, and TEC kinases are implicated in the sustained PLCγ1-Y783 phosphorylation observed after CD47 peptide triggering; and whether a direct relationship exists between CD47 and BCR or, as in other cell types [79,80], between CD47 and integrins. Here, PLCG1 is linked to B-cell chronic lymphocytic leukemia.