PLCG1 and B-cell chronic lymphocytic leukemia: As shown in Fig. 6E, the Mann-Whitney test (p < 0.001) indicated that the down-regulation of PLCG1 significantly diminished PKHB1-induced PCD in the primary CLL lymphocytes (~50% Annexin/PI co-positivity in control or scramble-transducted cells and less than 20% in B lymphocytes transducted with a shRNA PLCG1).