However, our data suggest that PKHB1-mediated PCD takes place in CLL cells via the induction of cellular alterations that are regulated by the ER and the signal transduction protein PLCγ1, but are independent from the fission protein DRP1, one of the major effectors of killing mediated by anti-CD47 mAb [55]. The gene discussed is PLCG1; the disease is B-cell chronic lymphocytic leukemia.