In addition, the gene expression profile of murine KrasG12D tumours devoid of STAT3 signalling significantly overlapped with human KRAS mutant lung AC, and, conversely, murine KrasG12D tumours competent of STAT3 signalling showed a significant enrichment for genes usually downregulated in human KRAS mutant lung AC (Supplementary Fig. 1h; ref. 24). Here, STAT3 is linked to neoplasm.