F2 and Venous thrombosis: Exposure of subendothelial matrix and release of prothrombin factors result in localized platelet adhesion and platelet activation and platelet-rich thrombus generation.16 Venous thrombosis seems to be a more important cause of flap necrosis than arterial occlusion.11 Prevention of platelet aggregation is one of the most important pharmacotherapy to prevent vessel’s thrombosis and subsequent flap necrosis.16