Several exome sequencing profiles of high-grade pediatric supratentorial and brainstem gliomas revealed a frequent, novel mutation of H3F3A, encoding histone variant H3.3, that is associated with poorer overall survival [8, 9]; among brainstem lesions, amplification of PDGFRA occurred exclusively in H3F3A-mutant tumors [10]. Here, PDGFRA is linked to brain stem glioma.