PDGFRA and malignant glioma: Genomic studies of pediatric high-grade gliomas (HGG) have demonstrated that the most frequent copy number aberration (CNA) is focal amplification of the platelet-derived growth factor receptor (PDGFRA) locus at chromosome 4q12, encoding the α isoform of platelet-derived growth factor receptor (PDGFRα) [4–7].