This is highlighted in a Belgian cohort of patients with ALS, where comparing familial C9orf72 carriers with non-C9orf72 FALS cases showed a significant increase in the frequency of bulbar onset, an increase in the age of onset, an increase in cases with a history of FTD, and a reduction in survival in C9orf72 ALS [31]. The gene discussed is C9orf72; the disease is frontotemporal dementia.