Also, a model to predict incident AD did not improve its results after adding CLU and PICALM to the considered variables of age, sex and ApoE, even though these genes have been confirmed to be associated with AD (changes in the Rotterdam Study from 0.847 to 0.849, and from 0.702 to 0.705 in the Cardiovascular Health Study) [29]. Here, APOE is linked to Alzheimer disease.