By design, controlled expression of Shp2CSDA in the progenitor cells of lung adenocarcinoma can be achieved by breeding the tetO-Shp2CSDA transgenic mice with CCSP-rtTA transgenic mice [25] and feeding the CCSP-rtTA/tetO-Shp2CSDA (C/Sdn) bitransgenic mice with Dox diet (Fig. 3B). The gene discussed is SCGB1A1; the disease is lung adenocarcinoma.