In each of EGFR-WT cells (SPC-A1 and A549), EGFR T790M mutant cells (NCI-H1975), or in Met-amplification cells (HCC-827GR), WB-308 caused severe inhibition effects when compared with Gefitinib (Figure 3), indicating that WB-308 should have less toxicity. This evidence concerns the gene EGFR and hepatocellular carcinoma.