At a concentration of 0.5 μM, WB-308 decreased the level of p-EGFR of EGFR-L858R stable cells even more severely than that in EGFR-WT stable cells at the concentration of 5 μM, which indicated that the NSCLC cell's sensitivity to WB-308 increased after EGFR mutation occurred (Figure 2B). This evidence concerns the gene EGFR and non-small cell lung carcinoma.