TNFRSF21 and neoplasm: Expression of FAS, DR3 and DR6 and DR downstream pro-apoptotic proteins including cleavaged caspase-3, -8 and -9 was concomitantly increased (Figure 1B), but the NF-κB activity and expression of pI03BAB and nucleus p50 and p65 were inhibited in tumor tissues by treatment with BV (Figure 1C).