The results indicated that COX-2-1195G/A exhibited the obvious association with HCC risk in heterogeneous, homozygous comparison and dominant model (GA vs GG: OR = 1.558, 95%CL 1.055–2.303, PA = 0.026; AA vs GG: OR = 1.466, 95%CL 1.194–1.801, PA = 0.000; GA+AA vs GG: OR = 1.356, 95%CL 1.148–1.602, PA = 0.000, Fig. 2). Here, PTGS2 is linked to hepatocellular carcinoma.