Moreover, large quantities of studies have confirmed the hypothesis that several COX-2 Single-Nucleotide Polymorphisms (SNPs) involving -1195G/A, -765G/C, and +8473T/C (SNP ID: rs689466, rs20417 and rs5275, respectively), were potentially correlated with HCC risk [10–18], but the results were rather controversial and unconvincing. Here, PTGS2 is linked to hepatocellular carcinoma.