Subgroup analysis by ethnicity (results are also listed in Table 3) indicated that -1195G/A polymorphisms of COX-2 was remarkably associated with HCC risk in Chinese population (A vs G: OR = 1.158, 95%CL 0.972–1.381, PA = 0.104; GA vs GG: OR = 1.203, 95%CL 0.987–1.467, PA = 0.068; AA vs GG: OR = 1.472, 95%CL 1.180–1.838, PA = 0.001, GA+AA vs GG:OR = 1.290, 95%CL 1.069–1.555, PA = 0.008, GG+GA vs AA: OR = 0.815, 95%CL 0.621–1.068, PA = 0.137). This evidence concerns the gene PTGS2 and hepatocellular carcinoma.