TAC1 and neuropathic pain: TCAs produce analgesia by various mechanisms, including sodium channels, N-methyl-d-aspartate receptors, biogenic amines, opioids, inflammatory mediators, and substance P. Studies have shown that intrathecal tricyclic administration effectively attenuates pain and thermal hyperalgesia in inflammatory and neuropathic pain in rats.<h4>Objectives</h4>The aim of this study was to evaluate the effect of two tertiary TCAs in sensory and motor block.