Karyotyping, fluorescent in situ hybridization (FISH), reverse transcriptase polymerase chain reaction (RT-PCR), and array-based methods for copy number analysis are routinely used to detect high hyperdiploidy (HeH, 51-67 chromosomes), the translocations t(9;22)(q34;q11)[BCR/ABL1], t(12;21)(p13;q22)[ETV6/RUNX1], t(1;19)(q23;p13.3)[TCF3/PBX1], 11q23/MLL-rearrangement, dic(9;20)(p13.2;q11.2), and intrachromosomal amplification of chromosome 21 iAMP21[RUNX1 X >3], which are recurrent in patients with ALL. The gene discussed is RUNX1; the disease is acute lymphoblastic leukemia.