Several of the genes highlighted in our classification procedure are associated with a somatic mutation or differential DNA methylation or gene expression patterns in ALL subtypes such as DDIT4L(4q23) in HeH [14,26], CBFA2T3(16q24), TCFL5(20q13.33), DSC3(18q12.1), and EPOR(19p13.3-p13.2) in t(12;21) [12,14,25-29], MBNL1(3q25) and ZEB2 (2q22.3) in 11q23/MLL [25,30], and NT5C2(10q24.32) and PON2(7q21.3) in t(9;22) [26,27,31,32]. The gene discussed is PON2; the disease is acute lymphoblastic leukemia.