Dr Edith Perez from the Mayo Clinic, Jacksonville, Florida, presenting on behalf of her colleagues upon stromal tumour-infiltrating lymphocytes (S-TILS) in HER-2 positive breast cancer demonstrated that lymphocyte predominant (LPBC) HER-2 positive breast cancer when treated with chemotherapy alone was associated with a significant improvement in relapse-free survival (RFS) (P = 0.009) compared to non-LPBC but this was not replicated when chemotherapy and trastuzumab were combined (P = 0.79). Here, ERBB2 is linked to breast cancer.