Dr Prudence Francis from the International Breast Cancer Study Group on behalf of colleagues described a randomised comparison of adjuvant tamoxifen (T) plus ovarian function suppression (OFS) versus tamoxifen in premenopausal women with hormone receptor-positive (HR+) early breast cancer (BC): analysis of the suppression of ovarian function (SOFT) trial [2]. Here, NR4A1 is linked to breast carcinoma.