Dr Christine Desmedt from the University of Brussels, Belgium and colleagues in their characterisation of lobular breast cancers discovered that CDH1, PIK3CA, TBX3, FOXA1, and the chromatin-related genes MLL2, MLL3, ARID1A, and ARID1B were more frequently mutated in ER positive/HER-2 negative invasive lobular cancer (n = 451) compared to the ER positive/HER-2 negative invasive ductal cancer (n = 266) from The Cancer Genome Atlas, whereas GATA3, TP53, and MAP3K1 were less frequently mutated. Here, ESR1 is linked to Hereditary breast cancer.