On the gene analysis of 59 patients diagnosed with male breast cancer, they found that the ER positive subgroup is characterised by somatic mutations in PI3K, GATA3, TP53 and MAP3K1, and that luminal B like tumours more frequently display GATA3 somatic mutations, mutations affecting DNA related-genes and 11q losses compared to luminal A cancers. The gene discussed is TP53; the disease is breast carcinoma.